Fri Aug 19 2022

45 articles - From Friday Aug 12 2022 to Friday Aug 19 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Ann Intern Med

Clinical Practice Guidelines From the Association for the Advancement of Blood and Biotherapies (AABB): COVID-19 Convalescent Plasma.

Recommendation 5 (prophylaxis) The AABB suggests against prophylactic CCP transfusion for uninfected persons with close contact exposure to a person with COVID-19 (weak recommendation, low-certainty evidence). Good clinical practice statement CCP is most effective when transfused with high neutralizing titers to infected patients early after symptom onset.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Left Atrial Appendage Occlusion Versus Oral Anticoagulation in Atrial Fibrillation : A Decision Analysis.

Although LAAO could be an alternative to anticoagulants for stroke prevention in patients with AF and high bleeding risk, the overall benefit from LAAO depends on the combination of stroke and bleeding risks in individual patients. These results suggest the need for a sufficiently low stroke risk for LAAO to be beneficial. The authors believe that these results could improve shared decision making when selecting patients for LAAO. Primary funding source None.

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Lancet

Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study.

Lesion swabs showed the highest viral loads, which, combined with the history of sexual exposure and the distribution of lesions, suggests close contact is probably the dominant transmission route in the current outbreak. Funding None.

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Early drug development in solid tumours: analysis of National Cancer Institute-sponsored phase 1 trials.

This study provides updated encouraging outcomes of modern phase 1 trials in solid tumours. Funding National Cancer Institute.

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Mepolizumab for urban children with exacerbation-prone eosinophilic asthma in the USA (MUPPITS-2): a randomised, double-blind, placebo-controlled, parallel-group trial.

Interpretation Phenotype-directed therapy with mepolizumab in urban children with exacerbation-prone eosinophilic asthma reduced the number of exacerbations. Funding US National Institute of Allergy and Infectious Diseases and GlaxoSmithKline.

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Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent a-thalassaemia or ß-thalassaemia: an open-label, multicentre, phase 2 study.

Interpretation These efficacy and safety results support the continued investigation of mitapivat for the treatment of both a-thalassaemia and ß-thalassaemia. Funding Agios Pharmaceuticals.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Lancet

India at 75 years: progress, challenges, and opportunities.

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Interstitial lung diseases.

Furthermore, we describe how developments have led to a shift in the classification and treatment of interstitial lung diseases that exhibit progressive pulmonary fibrosis and summarise the latest practice-changing guidelines. We conclude with an outline of controversies, uncertainties, and future directions.

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Letters&Replies

Letters to the editors and authors’ replies

Lancet

Data at 36 months for the Symplicity SPYRAL HTN-ON MED pilot - Authors' reply.

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Data at 36 months for the Symplicity SPYRAL HTN-ON MED pilot.

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Evidence of human-to-dog transmission of monkeypox virus.

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Iran's burden of disease and burden of data collection - Authors' reply.

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Iran's burden of disease and burden of data collection.

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Iran's burden of disease and burden of data collection.

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Screening policies for cytomegalovirus in pregnancy in the era of antivirals.

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Others

all remaining publications eg case reports, images of the month, etc…

Ann Intern Med

A Rich Vein.

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Annals for Educators - August 2022.

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Annals for Hospitalists - August 2022.

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Asymptomatic Infection? Another Reason to Consider Monkeypox a Disease of Public Health Concern.

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Bedside Manner.

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Detection of Monkeypox Virus in Anorectal Swabs From Asymptomatic Men Who Have Sex With Men in a Sexually Transmitted Infection Screening Program in Paris, France.

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Left Atrial Appendage Occlusion Versus Anticoagulation in Atrial Fibrillation: Equipoise When Bleeding Risk Is High.

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Major Update 2: Remdesivir for Adults With COVID-19.

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Major Update 2: Remdesivir for Adults With COVID-19.

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Summary for Patients: Occlusion Devices Versus Blood Thinners for Atrial Fibrillation.

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The Fast and the Furious: Chasing a Clinical Niche for COVID-19 Convalescent Plasma.

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Web Exclusive. Annals Consult Guys - Endocarditis Prophylaxis for Patients With TAVR.

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Web Exclusive. Annals for Hospitalists Inpatient Notes - Improving Medication Reconciliation in Hospitals.

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Web Exclusive. Annals On Call - Surgery for Mild PTH.

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Lancet

"You have not remained the same, nor have I".

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A historic opportunity for universal health coverage in India.

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An energy booster for thalassaemic red blood cells.

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Biologic therapies for asthma in underserved populations.

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Botswana's HIV/AIDS success.

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No clubbing in the fingers, only in the toes: patent ductus arteriosus and reversed shunting.

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Not misogynistic but myopic: the new women's health strategy in England.

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Participation in phase 1 trials for patients with cancer.

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Poornima Prabhakaran: advocate for health in a changing climate.

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Power and the planetary health equity crisis.

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Sexual behaviours and clinical course of human monkeypox in Spain.

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Thomas Bewley.

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Turkish doctors emigrate amid low pay and rising violence.

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N Engl J Med

From Survival to Survivorship - Framing Traumatic Injury as a Chronic Condition.

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Professionals as Targets in the Culture Wars.

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Rice Bodies in Tenosynovitis Due to Psoriatic Arthritis.

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